25 - 27 October, 2016
Novotel Berlin Am Tiergarten, Berlin, Germany

Dr. Robert Goodnow

Executive Director
Chemistry Innovation Center, AstraZeneca, USA

Robert Goodnow was born in Colorado, USA. Rob completed his BS in chemistry at Georgetown University followed by a Ph.D. in natural products organic chemistry at Columbia University. He continued research in oligosaccharide synthesis at Princeton University as an NIH Postdoctoral Fellow. Rob began his industrial career at Hoffmann-La Roche in the Antisense Research Group followed by extensive research in combinatorial chemistry and lead generation.  In addition to several medicinal chemistry project leadership responsibilities, Rob has managed multiple outsourcing collaborations for pre-clinical discovery chemistry on a local and global level, eventually becoming the Global Leader of Medicinal Chemistry Outsourcing. His research efforts have also supported small molecule targeted delivery of siRNA for therapeutic applications, analytical chemistry and DNA-encoded chemistry.  Rob has authored or co-authored more than 80 scientific papers, book chapters and patent applications.  Recently, he edited a book entitled “A Handbook of DNA-Encoded Chemistry”.  Since 2013, Rob has been the Executive Director of the Discovery Sciences Chemistry Innovation Centre at AstraZeneca.

17:30 Building compound archives for future targets

  • Will the targets of the future be covered by the chemical matter of today?

  • Do we have the tools that can answer this question?

  • The interplay between druggability and ligandability

  • Future directions

Panel discussion will be followed by an Open Mic session: Join the discussion with the panel of experts and find collectively possible approaches and solutions

09:45 DNA-encoded chemistry: Enabling the deeper sampling of chemical space for drug discovery

  • Cost effective exploration of chemical spaces four to five orders of magnitude more deeply than by HTS

  • New opportunities and challenges of DNA-encoded library technology

  • Aqueous synthetic chemistry and building blocks diversity

  • What value is coming out of this approach?

13:45 Workshop C - Intelligent library design and synthesis in practice: Strategies to build a screening collection

This is a practical workshop following the optimized workflow towards the design and synthesis of the desired compound libraries.

  • Design of the screening collection

  • Diversity and targeted libraries

  • Exploration of alternate screening modalities

  • Analysis of screening results

Check out the incredible speaker line-up to see who will be joining Dr. Robert.

Download The Latest Agenda