25 - 27 October, 2016
Novotel Berlin Am Tiergarten, Berlin, Germany

Dr. Richard Lewis

Global head, CADD
Novartis International AG, Switzerland

Richard A. Lewis earned his B.A. (1984) and Ph.D. (1988) from Cambridge University, under the supervision of Dr Philip Dean.  He performed postdoctoral studies as a Fulbright scholar in the lab of Prof Tack Kuntz and as a Royal Commission Fellow in the lab of Prof. Mike Sternberg before joining the team of Jon Mason at RPR in 1991.  In 1998 he joined Eli Lilly to lead the European modelling group, and then in 2004 moved to Novartis in Basel as head of Computer-aided Drug Design.  He has authored over 50 papers and patents, and is a fellow of the Royal Society of Chemistry.

17:30 Building compound archives for future targets

  • Will the targets of the future be covered by the chemical matter of today?

  • Do we have the tools that can answer this question?

  • The interplay between druggability and ligandability

  • Future directions

Panel discussion will be followed by an Open Mic session: Join the discussion with the panel of experts and find collectively possible approaches and solutions

10:15 Analyzing building blocks diversity for DNA Encoded Library (DEL) design

  • DNA encoding: An opportunity to build massive hit-finding libraries

  • The challenge to cover chemical space appropriately

  • Current methods for selecting building blocks focus on 2D similarity and new Rooted 2D fingerprints

  • Development of complementary field-based descriptors and new clustering methods

  • Combination of tools with DEL technology to address the chemical space needed for hit finding against difficult future targets

Check out the incredible speaker line-up to see who will be joining Dr. Richard.

Download The Latest Agenda