Workshop Day

08:15 AM - 08:30 AM Registration & welcome coffee

08:30 AM - 10:45 AM Workshop A - Interaction of screening, data analysis, library design and medicinal chemistry

Dr. Mark Hixon, Senior Fellow, Modeling & Simulation, Takeda Pharmaceuticals, USA
  • Compound Management

  • Overview about Screening Technologies

  • Screening Data Analysis

  • Library concepts of own synthesized compounds


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Dr. Mark Hixon

Senior Fellow, Modeling & Simulation
Takeda Pharmaceuticals, USA

10:45 AM - 12:45 PM Workshop B - Prioritization of biophysical methods relative to the drug target and its mechanism of modulation

Dr. Pawel Stanczak, Scientist, Dart Neuroscience, USA

This interactive experience-based workshop will address the following approaches:

  • Prioritization of biophysical techniques to increase the success rate and speed up the FBDD process.

  • Discussion on PPI targets and prioritization of biophysical screenings for PPI targets. Selection of "intelligently designed" fragment libraries for those classes of targets.

  • Discussion on membrane proteins targets (mostly GPCRs) and prioritization of biophysical screenings for GPCRs.

  • Discussion on alternatives in FBDD (lack of crystal structures, low hit rate, etc.) using NMR spectroscopy and other biophysical tools.


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Dr. Pawel Stanczak

Scientist
Dart Neuroscience, USA

12:45 PM - 1:45 PM Networking luncheon

1:45 PM - 4:00 PM Workshop C - Intelligent library design and synthesis in practice: Strategies to build a screening collection

Dr. Robert Goodnow, Executive Director, Chemistry Innovation Center, AstraZeneca, USA

This is a practical workshop following the optimized workflow towards the design and synthesis of the desired compound libraries.

  • Design of the screening collection

  • Diversity and targeted libraries

  • Exploration of alternate screening modalities

  • Analysis of screening results


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Dr. Robert Goodnow

Executive Director
Chemistry Innovation Center, AstraZeneca, USA

4:00 PM - 11:59 PM End of workshop day